|
KMID : 0370220100540010055
|
|
Yakhak Hoeji
2010 Volume.54 No. 1 p.55 ~ p.61
|
|
|
Protective Effect of Gardenia jasminoides Against Carbon Tetrachloride-Induced Acute Hepatotoxicity
|
|
Shin Jun-Kyu
Kim Hyo-Yeon
Lee Sun-Mee
|
|
|
Abstract
|
|
|
|
Gardenia jasminoides is one of the most widely used herbal preparations for the treatment of liver disorders. This study evaluated the potential beneficial effect of G. jasminoides in a mouse model of carbon tetrachloride ()-induced liver injury. The mice were treated intraperitoneally with (10 /kg). They received G. jasminoides (30, 100, 300 mg/kg) 48 h, 24 h and 2 h before and 6 h after administering . The serum activities of aminotransferase and the hepatic level of malondialdehyde were significantly higher 24 h after the treatment, while the concentration of reduced glutathione was lower. These changes were attenuated by G. jasminoides. increased the level of circulating tumor necrosis factor- (TNF-) markedly, which was reduced by G. jasminoides. The levels of hepatic inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression were markedly higher after the treatment. G. jasminoides diminished these alterations. increased the level of TNF-, iNOS and COX-2 mRNA expressions, and these increases were attenuated by G. jasminoides. These results suggest that G. jasminoides alleviates -induced liver injury, and this protection is likely due to the reduced oxidative stress and the downregulation of proinflammatory mediators.
|
|
|
KEYWORD
|
|
|
carbon tetrachloride, Gardenia jasminoides, hepatotoxicity, inflammation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|